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Cytoxan and canine anal glan carcinoma

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    Preliminary evidence for biologic activity of toceranib phosphate (Palladia®) in solid tumors

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    Preliminary evidence for biologic activity of toceranib phosphate (Palladia®) in solid tumors

    Ciclooxygenase inhibitor and metronomic chemotherapy association for the treatment of metastatic anal sac carcinoma in dog: case report. Teixeira 1. Bicalho 1. Vasconcelos 1. Cunha 1. Lavalle 1. Metronomic chemotherapy consists of an anticancer modality treatment.
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    Cases in which toceranib was used to treat dogs with anal sac anal gland adenocarcinoma, metastatic osteosarcoma, thyroid carcinoma, head and neck carcinoma, and nasal carcinoma were included. For dogs experiencing CB, the median dose of toceranib was 2. While these data povide preliminary evidence that toceranib exhibits CB in dogs with certain solid tumors, future prospective studies are necessary to define its true activity. It works as a competitive inhibitor of ATP, thereby preventing receptor phosphorylation and subsequent downstream signal transduction. Based on its structural and functional similarity to sunitinib Sutent toceranib likely also inhibits an additional RTK called Ret 4 , 5.
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