The incidences of human papillomavirus HPV -related anal cancer and its precursor lesion, anal intraepithelial neoplasia, are rising in the U. Five-year survival rates with current modalities of treatment for anal cancer are generally favorable for localized and regional disease. For metastatic disease, the relative survival rate is poor. Major contributing factors for the increase in anal cancer incidence include increasing receptive anal intercourse hetero- and homosexual , increasing HPV infections, and longer life expectancy of treated people who are seropositive for human immunodeficiency virus. Because treatment outcomes with systemic therapy in patients with advanced disease are so poor, prevention may be the best approach for reducing disease burden. The association of a major causative agent with anal cancer provides an excellent opportunity for prevention and treatment.
Meet the Vaccines
FDA approves HPV vaccine for anal cancer
The FDA announced today that it has approved the HPV vaccine for anal cancer and associated precancerous lesions related to human papillomavirus types 6, 11, 16 and The new indication is for patients aged 9 through 26 years. Gardasil Merck is already approved for the same age population for the prevention of cervical, vulvar and vaginal cancer and the associated precancerous lesions caused by HPV types 6, 11, 16, and 18 in women and girls, and for the prevention of genital warts caused by types 6 and 11 in both males and females. The American Cancer Society estimates that about 5, Americans are diagnosed with anal cancer annually. Approval for the new indication is based on a single randomized, controlled trial of 4, patients, including men who have sex with men. Because anal cancer is the same disease in both males and females, the effectiveness data was used to support the indication in females as well. Tell us what you think about Healio.
Prophylactic HPV vaccination and anal cancer
Skip to Content. Human papillomavirus HPV is usually passed from one person to another during direct skin-to-skin contact. HPV is the most common sexually transmitted infection in the United States. There are more than different types of HPV. Most men and women have no symptoms or health problems to indicate when they have HPV.
But there are things you can do that might lower your risk of anal cancer. Infection with HPV increases the risk of anal cancer. Vaccines are available that protect against certain HPV infections.